Regulation of collagen biosynthesis by ascorbic acid: a review.
نویسنده
چکیده
L-ascorbic acid is an essential cofactor for lysyl hydroxylase and prolyl hydroxylase, enzymes essential for collagen biosynthesis. In addition, L-ascorbic acid preferentially stimulates collagen synthesis in a manner which appears unrelated to the effect of L-ascorbic acid on hydroxylation reactions. This reaction is stereospecific and unrelated to intracellular degradation of collagen. The effect apparently occurs at a transcriptional or translational level, since L-ascorbic acid preferentially stimulates collagen-specific mRNA. In addition, it stimulates lysyl hydroxylase activity but inhibits prolyl hydroxylase activity in human skin fibroblasts in culture.
منابع مشابه
Collagen Biosynthesis
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——————————————— For Correspondence: Maria Wardas PhD, Department of Food and Nutrition, Silesian Academy of Medicine, 4 Jagiellońska Street, 41-200 Sosnowiec, Poland; E-mail: [email protected] The Institute of Experimental and Clinical Biochemistry, Department of Chemistry and Biochemistry, Silesian Academy of Medicine; Department of General and Analytical Chemistry, Silesian Academy of...
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ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 58 شماره
صفحات -
تاریخ انتشار 1985